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Health Status and Quality of Life in Young Adults of Extremely Low Birth Weight

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Abstract:

In cost-effectiveness analyses of health care interventions, differences in quality of life are commonly incorporated by measuring effectiveness in quality-adjusted life years, or QALYs. It is generally accepted that quality adjustments should be preference-based, and the standard gamble technique is often taken as the “gold standard” for eliciting preferences. Several instruments exist for classifying health states using a multi-dimensional index. In practice, it is very costly to elicit preferences by standard gamble for a broad range of possible health states. Therefore, for several of these instruments, “utility functions” have been estimated that map multi-dimensional health status into (health-related) quality of life. Such functions are estimated by applying statistical techniques to samples of data in which individuals have directly provided preference-based QALY values for particular health states described by the multidimensional index. Typically preferences are provided by the general public, not individuals experiencing the particular health states, in accord with the recommendations of the Panel on Cost-Effectiveness (Gold et al., Cost-Effectiveness in Health and Medicine, 1996).

This paper concerns a population-based cohort of 166 individuals born at Extremely Low Birth Weight (501-1000g) in Ontario, Canada between 1977 and 1982 who have been followed to young adulthood. Subjects’ health status has been assessed during recent interviews (at about age 23) using two commonly used instruments, the Health Utilities Index, (HUI2), and the SF-36. Subjects also rated their own health status (as they classified themselves on the HUI2), as well as four other hypothetical health states, by standard gamble. Mean scores on several domains of the HUI2 were significantly lower for the ELBW survivors than for a control group of normal birth weight young adults from the same geographic area and of similar socioeconomic status. However, as was found previously when a similar exercise was conducted at mid-teen-age (Saigal, et al., JAMA 1996), mean QALY scores were very similar between the two groups (mean score 0.85 for the ELBW, 0.88 for the NBW, with the difference not significant).

A utility function exists for mapping HUI2 scores into QALY scores, and several such functions have recently been developed for the SF-36. This paper will explore the relationship between QALY scores as predicted from health status using these functions and directly expressed QALY scores. It is hypothesized that positive correlations will exist between predicted and directly expressed scores, but that mean direct scores will be higher for the ELBW, especially for those in relatively poor health by “objective” measures. The implications of our findings for quality-adjustment in cost-effectiveness analysis will be discussed.
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Association:
Name: Economics of Population Health: Inaugural Conference of the American Society of Health Economists
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MLA Citation:

Goddeeris, John. and Saigal, Saroj. "Health Status and Quality of Life in Young Adults of Extremely Low Birth Weight" Paper presented at the annual meeting of the Economics of Population Health: Inaugural Conference of the American Society of Health Economists, TBA, Madison, WI, USA, Jun 04, 2006 <Not Available>. 2009-05-25 <http://www.allacademic.com/meta/p93396_index.html>

APA Citation:

Goddeeris, J. H. and Saigal, S. , 2006-06-04 "Health Status and Quality of Life in Young Adults of Extremely Low Birth Weight" Paper presented at the annual meeting of the Economics of Population Health: Inaugural Conference of the American Society of Health Economists, TBA, Madison, WI, USA <Not Available>. 2009-05-25 from http://www.allacademic.com/meta/p93396_index.html

Publication Type: Abstract
Abstract: In cost-effectiveness analyses of health care interventions, differences in quality of life are commonly incorporated by measuring effectiveness in quality-adjusted life years, or QALYs. It is generally accepted that quality adjustments should be preference-based, and the standard gamble technique is often taken as the “gold standard” for eliciting preferences. Several instruments exist for classifying health states using a multi-dimensional index. In practice, it is very costly to elicit preferences by standard gamble for a broad range of possible health states. Therefore, for several of these instruments, “utility functions” have been estimated that map multi-dimensional health status into (health-related) quality of life. Such functions are estimated by applying statistical techniques to samples of data in which individuals have directly provided preference-based QALY values for particular health states described by the multidimensional index. Typically preferences are provided by the general public, not individuals experiencing the particular health states, in accord with the recommendations of the Panel on Cost-Effectiveness (Gold et al., Cost-Effectiveness in Health and Medicine, 1996).

This paper concerns a population-based cohort of 166 individuals born at Extremely Low Birth Weight (501-1000g) in Ontario, Canada between 1977 and 1982 who have been followed to young adulthood. Subjects’ health status has been assessed during recent interviews (at about age 23) using two commonly used instruments, the Health Utilities Index, (HUI2), and the SF-36. Subjects also rated their own health status (as they classified themselves on the HUI2), as well as four other hypothetical health states, by standard gamble. Mean scores on several domains of the HUI2 were significantly lower for the ELBW survivors than for a control group of normal birth weight young adults from the same geographic area and of similar socioeconomic status. However, as was found previously when a similar exercise was conducted at mid-teen-age (Saigal, et al., JAMA 1996), mean QALY scores were very similar between the two groups (mean score 0.85 for the ELBW, 0.88 for the NBW, with the difference not significant).

A utility function exists for mapping HUI2 scores into QALY scores, and several such functions have recently been developed for the SF-36. This paper will explore the relationship between QALY scores as predicted from health status using these functions and directly expressed QALY scores. It is hypothesized that positive correlations will exist between predicted and directly expressed scores, but that mean direct scores will be higher for the ELBW, especially for those in relatively poor health by “objective” measures. The implications of our findings for quality-adjustment in cost-effectiveness analysis will be discussed.

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