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Association: Name: American Sociological Association URL: http://www.asanet.org
Citation: URL: http://www.allacademic.com/meta/p184976_index.html Direct Link: HTML Code:

Chimonas, Susan., Chen, Nancy., Bassett-Novoa, Eric., Moynihan, Patrick. and Rothman, David. "Does industry support bias research? Funding source and outcome in cardiovascular device trials" Paper presented at the annual meeting of the American Sociological Association, TBA, New York, New York City, Aug 11, 2007 <Not Available>. 2010-03-13 <http://www.allacademic.com/meta/p184976_index.html>

Chimonas, S. , Chen, N. Y., Bassett-Novoa, E. , Moynihan, P. J. and Rothman, D. J. , 2007-08-11 "Does industry support bias research? Funding source and outcome in cardiovascular device trials" Paper presented at the annual meeting of the American Sociological Association, TBA, New York, New York City Online <PDF>. 2010-03-13 from http://www.allacademic.com/meta/p184976_index.html

Publication Type: Conference Paper/Unpublished Manuscript Abstract: Background: Studies show that research funded by pharmaceutical and food manufacturers are likely to report results favorable to industry. However, no studies have examined the influence of commercial funding on medical device research. Objective: To determine whether there is an association between funding source and outcome in cardiovascular device trials. Methods: Randomized controlled cardiovascular device trials published in six journals from 2000 to 2006 were examined. Study outcome was classified as positive, negative, and uncertain. Funding was classified as industry support, non-profit support, mixed, and not cited. Industry-support was further classified into different types (consulting, patents, grants, etc.). The number of authors’ relationships with industry was also noted. Results: Of 143 articles, 74.83% had positive results, 20.98% had negative results, and 4.20% had uncertain results. Some form of industry support was found in 50.35% of studies. Negative results were found in 18.31% of industry-supported studies, 22.22% of mixed-support studies, 22.58% of non-profit supported studies, and 26.09% of studies in which no source was cited. Direct financial benefit to the investigator - in the forms of stock, equity, royalties, or salary - was associated with an increased likelihood of positive outcomes. Having multiple industry relationships was associated with outcomes favorable to companies. Conclusions: Industry support may pose financial conflicts of interests in device development. The results of this study emphasize the importance of full financial disclosure. Additional regulation of funding relationships in device research may be warranted.

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